The Archon Genomics XPRIZE presented by Express Scripts

This is a prize about all of us.

This global, incentivized competition will inspire breakthrough genome sequencing innovations and technologies with the potential to create a new era of personalized medicine. $10 million will be awarded to the first team to rapidly, accurately and economically sequence 100 whole human genomes to an unprecedented level of accuracy.

The 100 human genomes to be sequenced in this competition will be donated by 100 centenarians (ages 100 or older) from all over the world, known as there 100 Over 100. Sequencing the genomes of the 100 Over 100 presents a unique opportunity to identify those "rare genes" that protect against disease, while giving researchers valuable clues to health and longevity.

Partnering For a Global Consensus

The Archon Genomics XPRIZE presented by Express Scripts and Nature Genetics partnered to create an open forum to the worldwide genetics community to help further define appropriate standards for measuring the quality of whole human genome sequencing as well as create an international consensus on a standard with the creation of the Validation Protocol.

Since this PRIZE was first launched in 2006, DNA sequencing technologies both in terms of speed and reduction in costs continue to advance. However, no current human genome sequence is fully complete, fully accurate or certain to contain all rearrangements or information of chromosome phasing (haplotype). Highly repetitive and other regions remain difficult to sequence but are likely critical in defining heritable features. The Validation Protocol was built to address all of the above, as well as declare the $10 million winner of the Archon Genomics XPRIZE presented by Express Scripts, then may be used as an industry standard thereafter.

Thus, the ideals of this PRIZE remain as critical for the future of human genetics and genetic medicine as ever.

Key collaborators in development of the Validation Protocol are:

  • Coriell Institute for Medical Research, Camden, NJ
  • EdgeBio, Gaithersburg, MD
  • Harvard School of Public Health, Boston, MA
  • The Human Genome Organization (HUGO), Singapore, Thailand
  • The J. Craig Venter Institute (JCVI), Rockville, MD and San Diego, CA
  • The National Center for Supercomputing Applications (NCSA), Urbana, IL
  • Nature Genetics, New York, NY